Skip to main page content home onlinefirst current issue past issues subscriptions alerts feedback aacr publications aacr home search go advanced search user name password sign in a case of diffuse neurofibromatosis involving the cranial, peripheral and sympathetic nerves, accompanied by tumor of the hypothalamus ernest e.
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Aegerter , m.
1 and lawrence w. Smith , m.
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1 1 department of pathology of temple university hospital and school of medicine, philadelphia abstract in 1860 kã¶lliker (1) described a disease which was chiefly characterized by multiple discrete tumors in the skin and subcutaneous tissues. instructions on using viagra In 1882 von recklinghausen (2) established the relationship between these tumors and the peripheral nerves. best place online to buy viagra He believed them to be neoplastic hyperplasias of the fibrous supportive tissue of the nerve trunks.
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He described the disease in its clinical aspects as it is recognized today. best place online to buy viagra Classically the disease presents multiple firm, movable, often protruding nodules in the epidermis or corium, which are frequently painful.
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The skin over them may be pigmented or there may be large, irregular, macular, chestnut-colored areas which may seem to have no relation to the tumor lesions.
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There may be concomitant multiple pigmented nevi.
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The tumors are usually benign but may undergo sarcomatous changes.
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Microscopically they usually present interlacing columns of fibers which tend to show hyalinization. best place online to buy viagra Since the original discussions an immense literature has grown up concerning the subject.
The tumors may be large, poorly defined masses of nerve trunks in the subcutaneous tissue or viscera, these being called plexiform neurofibromas. Association has been described not only with nevi and macular pigmented areas, but with xanthomata, multiple lipomata, elephantiasis, and with tumors of sebaceous and sweat glands. side effects viagra girls The complexity is increased when diffuse or nodular involvements of the sympathetics are included.
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These tumors may apparently be limited to hyperplasias of the sympathetic system or be only a part of a more generalized involvement in which the sensory and motor peripheral nerves also participate. viagra online bestellen forum Tumors of the roots of th.
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